Does Clomid Work and What Are the Side Effects?
A woman is born with hundreds of thousands of eggs. It is said to release an egg every month through ovulation. It is well known that a pregnant woman must fertilize the egg. However, fertilization cannot take place if ovulation does not occur.
Failure to ovulate is called anovuulation in medical language. It can be treated with a number of medicines, including clomid, which contains an active ingredient called clomiphene citrate.
Mechanism of action
For a woman to ovulate, many hormonal events come into play and Clomid increases the level of these hormones. The hormones in question are luteinizing hormone (LH), gonadotropin-releasing hormone (GnRH) and follicle stimulating hormone (FSH). Together, these hormones stimulate your ovaries to release an egg.
The sex hormone estrogen usually sends messages to the brain to stop the release of these hormones. Clomid therefore stops or inhibits this estrogen effect in order to enable unhindered ovulation.
In addition to treating anovuulation (ovulation failure), Clomid is also used to treat irregular menstruation and polycystic ovarian syndrome (PCOS).
How to use Clomid
You should only follow your doctor's instructions if you are using a medicine. Taking a medicine based on a prescription consulted on the Internet can pose a serious risk. However, some of the diets used include days 3-7 of your period or days 5-9. The dose is also determined by your doctor and is between 50 mg and 200 mg.
Clomid and other fertility drugs cause autism
On May 20, 2010, researchers from the Harvard School of Public Health presented the results of a study that looked at the possible link between fertility drug use and autism spectrum disorder (ASD). Scientists told attendees at the Philadelphia International Autism Research Meeting that women who used fertility drugs to get pregnant were almost twice as likely to have a child with ASD compared to non-users. The medicinal products examined included clomid (clomiphene citrate) and pergonal (gonadotropin).
This latest study is part of a growing body of research that supports the argument that Clomid and other similar drugs are a cause of ASA, as they can deny a developing embryo cholesterol soon after conception. , About 58% of children with ASA have low total cholesterol (
Clomid has a long half-life and is present during the embryonic period (the first 8 weeks), even if it is taken before conception. Studies have shown that it is biologically active up to 54 days after ingestion and can accumulate over successive treatment cycles. In the Harvard study, they found that the longer they took fertility drugs, the higher the risk of developing ASA. An extremely important fact - and one that most doctors cannot prescribe - is that clomid is a cholesterol inhibitor and affects its production by acting on enzymes in the body that are similar to Lipitor and other statins. The chemical structure is also similar to that of the cholesterol-lowering active ingredient triparanol, which was briefly available in the 1960s. Animal studies have shown that clomid and triparanol act on the same enzyme and have the same effect on developing organs. Triparanol is a little stronger.
Pergonal (also known as human menopause gonadotropin or hMG) also lowers cholesterol, but through a different mechanism. It suppresses cholesterol in early pregnancy because of its ability to increase estrogen production. Studies have shown that after pergonal overstimulation of the ovaries, the resulting high estrogen level during the luteal phase (after ovulation) lowers the total cholesterol level. In fact, there is an inverse correlation between estrogen concentrations and total cholesterol - the higher the estrogen level, the lower the total cholesterol concentration.
The GOOD NEWS is that many children with low-cholesterol ASA treated with cholesterol supplements showed a dramatic improvement. Scientist from Johns Hopkins University Medical Center, led by Dr. Richard Kelley has shown such a treatment that leads to an improvement in mobility, verbalization, growth, behavior, sociability and vigilance. Most importantly, once we have a thorough understanding of an ASD cause, we can eliminate this cause and reduce the number of families affected by this tragic anomaly.